SIN groups

31 SIN groups

The SIN List is divided into 31 groups based on structural similarity which in turn can be linked to toxicological effects.

All substances but about 60 have been assigned to one or more groups. Since many compounds contain several of these group specific structural elements, one chemical can belong to multiple groups.

The group names are, when possible, based on common names that are also familiar to non­chemists, e.g. “Phthalates” and “Parabens”. We have also kept the numbers of groups down by using broad definitions of the structural elements.

– Besides facilitating the task of SIN List users, the grouping of the SIN List and the SINimilarity tool aim to spark debate about what kind of chemicals regulation we need for the future. REACH is based on a chemical-by-chemical approach, but future chemicals legislation also needs to act on groups of similar chemicals, commented Dr Anna Lennquist, ChemSec toxicologist, when the SIN List update including grouping of the list was presented 8 October 2014.


The 31 SIN List groups are:

  • Alkylphenols
  • Amino carbonyl compounds
  • Antimony compounds
  • Aromatic amines
  • Arsenic compounds
  • Azo compounds
  • Beryllium compounds
  • Bisphenols
  • Boron compounds
  • Cadmium compounds
  • Chromium compounds
  • Cobalt compounds
  • Electrophiles
  • Glycol ethers
  • Hydrazines
  • Lead compounds
  • Mercury compounds
  • Mineral fibres
  • Nickel compounds
  • Nitro compounds
  • Nitrosamines
  • Organotin compounds
  • Parabens
  • Perfluorinated compounds
  • Petroleum
  • Phthalates
  • Polyaromatics
  • Polyhalogenated aromatics
  • Polyhalogenated alkanes
  • Polyhalogenated alkenes
  • Thioamino carbonyl compounds